Human Brain Evolution

The human brain is the seat of our cognition, behavior, and much of what makes us uniquely human. These capabilities are rooted in the complex transcriptional, regulatory, and epigenetic programs governing the development of cell types and functionally distinct regions of the brain. Therefore, some of these programs are likely specific to the human brain. Better understanding of how developing human brain differs from that of closely related non-human primates is fundamental for teasing out human-specific aspects of behavior, cognition, and psychiatric, and neurological disorders.

Here, we present the generation and comparative analysis of tissue-level RNA-seq datasets covering prenatal and postnatal periods of human and macaque brain development as well as single-cell and single-nuclear analysis of gene expression in midfetal development and adulthood, respectively.